Silicon microgrooves for contact guidance of human aortic endothelial cells

• Sara Fernández-Castillejo,
• Pilar Formentín,
• Úrsula Catalán,
• Josep Pallarès,
• Lluís F. Marsal and
• Rosa Solà

Beilstein J. Nanotechnol. 2017, 8, 675–681, doi:10.3762/bjnano.8.72

• microscale features to mimic the endothelium in lineal vessels. Keywords: cell morphology; contact guidance; microgrooves; silicon; human aortic endothelial cells (HAECs); Introduction Micro- and nanostructured materials for medical devices have demonstrated that surface topography as well as surface

• , macroporous and micropillars, to study the effect of topography on the behaviour of endothelial cells. Collagen was found to stimulate cell adhesion and promote an enhanced cell attachment [32][33]. Herein, to mimic the elongated endothelium in natural lineal vessels, human aortic endothelial cells (HAECs

• incubating the silicon substrates with human aortic endothelial cells (HAECs). Blank control values (cells seeded in the absence of any silicon substrates) were set at 100% and the other conditions were calculated in relation to this reference value. As shown in Figure 3, no cytotoxicity was observed as no